Endocrine Abstracts

Therapeutic response for medical therapy in hormonally functioning pituitary tumours is different in various types of tumours. While majority of prolactinomas respond well for medical therapy using dopamine agonists, in other tumours like somatotropinoma or corticotropinoma their response is significantly lower. In some case therapy resistance can occur. There are various factors determining the efficacy of medical therapy in patients harboring functioning pituitary adenomas. ...

Different hormonal disorders can influence bone metabolism and cause secondary osteoporosis. In childhood, pituitary disorders hamper gaining of proper peak bone mass and skeletal size, later on in the adult life they can increase bone loss. The consequence of diminished bone strength is significant increase of fracture risk. Among pituitary disorders such effects are possible in patients with GH, prolactin, gonadotropins secretion disturbances, and GH and ACTH excess, while h...

Osteoporosis is the most common metabolic bone disease. It represents significant burden due to fractures and costs for the health system and individuals. There are several factors which increase the risk of osteoporosis, genetic, hormonal and environmental influences are the most important. The primary goal of early intervention is to prevent the fractures. This could be carried out by the influence on bone density and quality, normalization of bone turnover, regulation of ho...

Patients with acromegaly have 2–3 fold increased mortality from cardiovascular diseases. It is associated with elevated growth hormone (GH) levels. Alterations of acute phase proteins, observed in patients with acromegaly, could lead to increased cardiovascular mortality. There are limited data on influences of GH excess on acute phase reactants.The aim of the study was to evaluate selected acute phase proteins levels: fibrinogen and C-reactive prot...

Obesity and overweight are nowadays very important health problems. Metabolic syndrome increases the risk of diabetes mellitus and coronary heart disease. Patients suffering from metabolic syndrome, especially males, are at greater risk of acute cardiovascular episodes, like heart infarct or brain stroke, than patients without this, widely accepted atheromatosis’ risk farctor. The aim of the study was assessment of possible relations of PPARγ genetic polymorphism and...

Introducing: Acromegaly is characterized by excessive GH and IGF1 secretion. Recent date suggests that soluble α-Klotho is also elevated in patients with acromegaly.Objective: The aim of this study was to assess the serum levels of soluble α-Klotho in patients in relation with the activity of disease and to compare with control group (CG). We also examine the relationship between excess GH, IGF1 and serum levels of soluble α-Klotho in pati...

Objective: Acromegaly has an important impact on health-related quality of life. The aim of study was to ascertain the quality of life of patients with uncontrolled vs controlled acromegaly and compared to those with non-functioning adenomas and healthy control group.Methods: 124 participants underwent a cross-sectional assessment including the quality of life (AcroQoL, WHOQoL BREF), psychiatric morbidity (GHQ-28) and acceptance of illness (AIS). The sam...

Pituitary tumor is a rare endocrine disorder. In the majority of cases, they are secreting prolactin and/or GH. Pituitary metastatic tumors are localized more often in the nervous than adenomatous hypophysis. Lung, breast and large intestine cancers metastases are found in the pituitary in the most cases. They cause hypopituitarism and local complications. The most often complications found are an optic nerve chiasm pressure or infiltration with a visual field loss, cavernous ...

Objective: The cross-sectional study was designed to assess the psychosocial profiles of patients with acromegaly and with non-functioning adenomas in correlation with the severity of the diseases.Methods: Forty-one patients with acromegaly and thirty-one with non-functioning adenomas underwent a cross-sectional assessment regarding their socio-demographic and medical profiles, including the quality of life, psychiatric morbidity, and acceptance of illne...

Understanding the genetic etiology of Graves’ disease (GD) and Graves’ orbitopathy (GO) is recognized as an urgent priority. Since peroxisome proliferator-activated receptors α (PPARα) exhibit anti-inflammatory and immunomodulatory activity, and are required for the control of the adipose inflammation process their role in the GD and GO pathogenesis has been proposed. Abnormal expression and/or function of PPARα could suppress the inflammatory response...